MDSi (Multi-omics Database for Setaria italica) is a comprehensive platform for foxtail millet, integrating genomics, transcriptomics, and metabolomics data. It features the high-quality xiaomi genome with 34,436 protein-coding genes, expression profiles across 29 tissues visualized via an electronic fluorescent pictograph (xEFP), and whole-genome resequencing data from 398 accessions, including 4.15 million SNPs and InDels. The database also provides metabolic data, gene co-expression networks, transcription factors, and transposable elements. Users can access tools for BLAST, genome browsing (GBrowse/JBrowse), variation search, and trait visualization. MDSi supports functional genomics and breeding research by offering a user-friendly interface and free data download.